Research

We investigate neural circuits and cell types with advanced optical and electrophysiological technologies, asking how the brain communicates in both normal and unhealthy conditions. Our work centres on two disease areas.

Research directions

Drug-resistant epilepsy →

In drug-resistant epilepsy, we track single-cell and population voltage dynamics across different neuronal cell types and brain regions, and across multiple timescales — within individual seizures, across successive seizures, and over the course of epileptogenesis. To do this we combine multimodal recordings — voltage imaging, electrophysiology, locomotion kinetics and behaviour — to follow how normal circuit communication breaks down.

Parkinson's disease →

Deep brain stimulation is a powerful therapy for Parkinson's disease whose mechanism is still poorly understood. We study how stimulation, from conventional to kilohertz frequencies, reshapes activity in the basal ganglia circuits affected in the disease, from single-cell responses to population dynamics. We combine multimodal recordings — electrophysiology, locomotion kinetics and behaviour — working toward more precise and effective stimulation.